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fhuC [2017-11-16 15:26:57]
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fhuC [2017-11-16 15:26:57]

hydroxamate siderophore ABC transporter (ATP-binding protein) (ferrichrome und ferrioxamine)
locus
BSU33290
pI
6.50
mw
29.80 kDa
protein length
269 aa Sequence Blast
gene length
807 bp Sequence Blast
function
siderophore uptake
product
hydroxamate siderophore ABC transporter (ATP-binding protein) (ferrichrome und ferrioxamine)
essential
no
ec
3.6.3.34
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores]
  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    3,415,387 → 3,416,196

    The protein

    Catalyzed reaction/ biological activity

  • ATP + H2O + iron chelate(Out) = ADP + phosphate + iron chelate(In) (according to Swiss-Prot)

    • Structure

  • [PDB|4R9U], the ''E. coli'' BtuC-BtuD complex, BtuD shares 34% identity, 55% similarity with FhuC, [Pubmed|25402482]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|3E1C925C31C00803982C8EB1C6B025C22DB4A828|fhuB]-[gene|EC98685EE0E3CE6CE8DC33409481AE96315279AC|fhuG]-[gene|E70BE74D5AB4B06CDFF902E58A0B9EBF477E21EC|fhuC]

    description

  • [pubmed|22383849]

    • regulatory mechanism

  • [protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]: repression, [pubmed|12354229], in [regulon|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur regulon]

    • regulation

  • induced by iron starvation (second wave to allow iron scavenging from the environment) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]) [pubmed|29133393,12354229]
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    Biological materials

    Mutant

  • BKE33290 (Δ[gene|E70BE74D5AB4B06CDFF902E58A0B9EBF477E21EC|fhuC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33290 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTCGGCCCCCTCCTCT, downstream forward: _UP4_TGAAAAAATCCCGGTTTGAA
  • BKK33290 (Δ[gene|E70BE74D5AB4B06CDFF902E58A0B9EBF477E21EC|fhuC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33290 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTCGGCCCCCTCCTCT, downstream forward: _UP4_TGAAAAAATCCCGGTTTGAA

    • References

  • 10092453,16672620,25402482,12354229